Research by Eves et al. (2021) examines the long-term cognitive outcomes of individuals born very preterm (VPT) or with very low birth weight (VLBW) compared to those born at term. The study uses a comprehensive meta-analysis of individual participant data (IPD) from multiple cohorts to identify factors contributing to differences in adult IQ.
Background
Individuals born VPT or with VLBW face higher risks of developmental challenges throughout life. Understanding how these early-life conditions affect adult cognitive outcomes can guide interventions aimed at mitigating long-term impacts. This research synthesizes data from studies conducted between 1978 and 1995, including over 2000 participants, to explore these relationships in depth.
Key Insights
Risk Factors: Lower gestational age, reduced birth weight z-scores, neonatal bronchopulmonary dysplasia, intraventricular hemorrhage, and lower maternal education levels were strongly linked to reduced IQ in adulthood.
- Differences in IQ: Adults born VPT or with VLBW scored on average 12 IQ points lower than those born at term, equating to a difference of 0.78 standard deviations.
- Risk Factors: Lower gestational age, reduced birth weight z-scores, neonatal bronchopulmonary dysplasia, intraventricular hemorrhage, and lower maternal education levels were strongly linked to reduced IQ in adulthood.
- Protective Interventions: Addressing neonatal complications and improving access to maternal education are identified as strategies to enhance cognitive outcomes for individuals born VPT or with VLBW.
Significance
This research highlights the persistent impact of early-life health and social factors on adult cognitive abilities. By identifying modifiable risks, such as neonatal care and maternal education, the study provides actionable insights for improving long-term outcomes for at-risk populations. These findings underscore the value of coordinated efforts across healthcare and education systems.
Future Directions
Further research could expand on this work by exploring the role of additional environmental and genetic factors in shaping cognitive outcomes. Longitudinal studies involving more diverse populations may also provide insights into broader applicability and guide policies aimed at reducing disparities in cognitive development.
Conclusion
The findings of Eves et al. (2021) emphasize the importance of addressing both biological and social determinants in supporting individuals born VPT or with VLBW. Through targeted interventions, it is possible to improve the long-term cognitive potential of these populations, contributing to more equitable outcomes in adulthood.
Reference
Eves, R., Mendonça, M., Baumann, N., Ni, Y., Darlow, B. A., Horwood, J., Woodward, L. J., Doyle, L. W., Cheong, J., Anderson, P. J., Bartmann, P., Marlow, N., Johnson, S., Kajantie, E., Hovi, P., Nosarti, C., Indredavik, M. S., Evensen, K.-A. I., Räikkönen, K., Heinonen, K., Zeitlin, J., & Wolke, D. (2021). Association of very preterm birth or very low birth weight with intelligence in adulthood: An individual participant data meta-analysis. JAMA Pediatrics, 175(8), e211058. https://doi.org/10.1001/jamapediatrics.2021.1058
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Read more →Why is background important?
Individuals born VPT or with VLBW face higher risks of developmental challenges throughout life. Understanding how these early-life conditions affect adult cognitive outcomes can guide interventions aimed at mitigating long-term impacts. This research synthesizes data from studies conducted between 1978 and 1995, including over 2000 participants, to explore these relationships in depth.
How does key insights work in practice?
Differences in IQ: Adults born VPT or with VLBW scored on average 12 IQ points lower than those born at term, equating to a difference of 0.78 standard deviations. Risk Factors: Lower gestational age, reduced birth weight z-scores, neonatal bronchopulmonary dysplasia, intraventricular hemorrhage, and lower maternal education levels were strongly linked
